Blobel was born in Waltersdorf, Germany. He graduated at the University of Tübingen in 1960. He was appointed to the Howard Hughes Medical Institute in 1986.
Blobel was awarded the 1999 Nobel Prize in Physiology or Medicine for the discovery that newly synthesized proteins contain "address tags" which direct them to the proper location within the cell. This is known as protein targeting.
As of 2003, Blobel works at the Rockefeller University, New York.
1978: National Academy of Sciences' U.S. Steel Foundation Award in Molecular Biology
1982: Gairdner Foundation International Award
1993: Albert Lasker Basic Medical Research Award
1995: Ciba Drew Award in Biomedical Research
1996: King Faisal Award
1997: Mayor's Award for Excellence in Science and Technology
1999: Nobel Prize in Physiology or Medicine